| Get all golds or higher in Honorary League | Changeling |
| Beat "The Hooded Man" under Easy difficulty or higher | Berseker Splitter |
| Beat 'Ninja garden' with bronze or higher | Chinese Chef |
| Beat Zany Zeppelin | Booty Guard |
| Beat"The Khallos Express" on Story Mode under Normal difficulty or higher | Elite Henchwoman |
| Beat Outbreak Hotel | Big Heads Cheat |
| Beat 'Old blaggers' wih bronze or higher. | Braces |
| Get Bronze or better on the Honorary League Arcade challenge "Lip Up Fatty" | Dozer |
| Beat the Cut-Out Shoot-Out Challenge "Balls of Steel" | Badass Cyborg |
| Beat 'Dont Loose Your Bottle' challenge | Bricks |
| Get Bronze or higher on the Challenge "Rare Or Well Done" | Carrion Carcass |
| Get Bronze or higher on the Amateur Arcade League challenge "Pirate Gold" | Captain Ed Shivers |
| Beat I Like Dead People | Deadwina |
| Get Bronze, Silver or Gold in Zone Control Arcade League. | Cascade cheat |
| Beat"Future Perfect" in Story Mode on Normal difficulty or higher | Corp Hart |
| Beat all Story Mode levels in Co-op | Daisy Dismay |
| Beat Challenge "Melon Heist" with a Bronze or Higher | Elite Henchman |
| Beat"U Genius, U-Genix" under Normal difficulty or higher | Dr. Cortez |
| Get all golds or higher in Amateur League | Dr. Peabody |
| Beat story level "What Lies Below" on Easy or higher | Dr. Lancet |
| Beat Communing Will Kill You with Bronze, Silver, Gold, or Platinum | Fat Characters |
| Beat Virtual Brutality | Fergal Stack |
| Beat Challenge "The Cat's Pajamas" with a Bronze or Higher | Gilbert Gastric |
| Beat Amateur League with all silvers or golds | Gideon Gout |
| Beat story level "Machine Wars" on Normal or higher | Ghengis Kant |
| Beat 'Freak unique' with bronze or higher | Hans |
| Beat Story level "Mansion of Madness" on Normal or higher | Gaston Boucher |
| Beat Elite League with all golds | INSETICK SD/10 |
| Beat the Scotland level, the 2nd level in Story Mode, on Normal to unlock the Flare Gun x2 in muliplayer. | Flare Gun x2 |
| Beat the Scotland level, the 2nd level in Story Mode, on Normal to unlock the Flare Gun in muliplayer. | Flare Gun |
| Beat "Breaking And Entering" on Story Mode under Normal difficulty or higher | Jack Sprocket |
| Beat "The Russian Connection" on Story Mode under Normal Difficulty or higher. | Henchman Cortez |
| Beat Story Mode Level 2234: Something to Crow About on Normal difficulty | Goliath SD/9 |
| Beat the challenge "Come Hell or High Water" with Bronze or higher | Goddard |
| Get Bronze, Silver or Gold in Cat's Out Of The Bag challenge. | Human Gun Sounds |
| Beat "Future Perfect" on Story Mode under Easy difficulty or higher | Jacob Crow |
| Beat Vamping In Venice | Jacque de la Morte |
| Beat all Story Mode levels in Co-op | Jim Smith |
| Beat "A Pox of Mox" with a bronze, silver, or gold. | Koozer Mox |
| Get bronze or better on challenge "brass monkeys" | Mischief |
| Beat "Sock it to them" with bronze or higher | Mr. Socky |
| Beat "The Khallos Express" on Story Mode under Easy difficulty or higher | Kitten Celeste |
| Beat "Future Perfect" in Story Mode on Hard difficulty | Karma Crow |
| Get a Bronze or above in the Electro Chimp Discomatic challenge. | Monkey Gun |
| Get a Gold on all of the Challenges | Jed |
| Get bronze or better on challenge "glimpse of stocking" | Mr. Underwood |
| Beat "Future Perfect" on Story Mode under Easy difficulty or higher | Mad Old Crow |
| Beat Scotland the Brave On Easy or better | Jungle Queen |
| Beat I Like Dead People | Old Film Cheat |
| Beat TSUG: Timesplitters Underground | Oleg |
| Beat Missle Bunker | Nurse Sputum |
| Beat "The Freak Unique" with atleast a Bronze Medal. | Neophyte Constance |
| Beat "Communing Will Kill You" with Bronze, Silver, Gold, or Platinum | Leonid Complete |
| Beat "What Lies Below" on Story Mode under Normal difficulty or higher | Jo-Barf Creepy |
| Beat all Challenges with all at least a Bronze Medal. | Mr. Fleshcage |
| Complete "Screw Loose" with atleast a Bronze Medal. | Prison Officer |
| Get a Bronze or higher on the Challenge "Plainly Off His Rocker" | Pulov Yuran |
| Beat the challenge "Hart Attack" with at least a bronze. | Viola |
| Beat "Plainly Off His Rocker" | Pulov Yuran |
| Get a Gold on Challenge "Absolutely Potty" | Paintball Cheat |
| Beat all Challenges with atleast all Silver Medals. | Sewer Zombie |
| Get Bronze or higher on the Challenge "Lap It Up" | Venus |
| Beat "You Take The High Road" on Story Mode under Normal Difficulty or higher. | Robot Louis Stevenson |
| Beat "Rockets 101" with a Bronze medal or higher | Slow Motion Deaths |
| Beat "You Take The High Road" on Story Mode under Easy difficulty or higher | Time Assassin Cortez |
| Beat "Virtual Brutality" | Prometheus SK/8 |
| Beat "Dehead the Undead" with either a bronze, a silver, or a gold | Spinning Heads |
| Beat "Divine Immolation" with Bronze, Silver, Gold, or Platinum | The Master |
| Beat "The Russian Connection" on Story Mode under Easy difficulty or higher | Swinging Tipper |
| Beat "Brain Drain" | Rotating Heads Cheat |
| Beat "The Hooded Man" in Story Mode on Normal difficulty or higher | Time Assassin |
| Beat "Future Perfect" in Story Mode on Normal difficulty or higher | Victorian Crow |
| Beat the whole Amateur League with Silver or higher | Warrant Officer Keely |
| Get a Bronze, Silver or Gold in Brain Drain Challenge. | Zombie Monkey |
| Get a Bronze or higher on the Challenge "Brain Drain" | Brains |
