| Choked Up (Bronze) | First kill with a Gas Mine. |
| Cleaning Up (Bronze) | First kill with a Mop Handle. |
| Congratulations (Platinum) | Acquired all trophies. |
| Curb Stomp (Bronze) | Stomped first Minion to death. |
| Darwin Would Be Proud (Bronze) | Died once. |
| Duress (Silver) | Kill 20 minions. |
| Fire Hazard (Bronze) | First kill with fire. |
| Forced Entry (Bronze) | Unlocked first door. |
| Give Me Five! (Bronze) | First kill with a Mannequin Arm. |
| Grave Digger (Bronze) | First kill with a Shovel. |
| Hatchet Job (Bronze) | First kill with a Hatchet. |
| Homerun (Bronze) | First kill with a Bat. |
| I Can Stop Anytime (Silver) | Used 20 Health Syringes. |
| I'm In Charge (Bronze) | Fought first NPC. |
| It Was An Accident (Bronze) | Kill first minion. |
| Just Experimenting (Bronze) | Used Health Syringe for the first time. |
| Kill Or Be Killed (Silver) | Killed a Collared Minion with a collar detonation. |
| Lights Off (Bronze) | First kill with a Table Lamp. |
| Locksmith (Bronze) | Unlock 5 locked doors. |
| Merciless (Silver) | Stomped five Minions to death. |
| Penetrated (Bronze) | First kill with a Syringe. |
| Pipe Dream (Bronze) | First kill with a Pipe. |
| Professional (Silver) | Unlock 20 locked doors. |
| Say Hello To My Little Friend (Bronze) | First kill with a Gun. |
| Self-Defense (Bronze) | Kill 10 minions. |
| Sometimes It Sticks (Bronze) | First kill with a Nail Bat. |
| Splitting Headache (Bronze) | First kill with Scissors. |
| Surgeon (Bronze) | First kill with a Scalpel. |
| Treasure! (Bronze) | Unlock first container. |
| Wait For The Boom (Bronze) | First kill with an Explosive Mine. |
| Who Is The Jigsaw Killer? (Bronze) | Find your first Patient File. |
| Whoops! (Bronze) | First kill with a Stun Mine. |
| Would You Like To Know More? (Bronze) | Find your first Asylum File. |
| You'll Need This Afterwards (Bronze) | First kill with a Crutch. |
| You've Been Served (Bronze) | First kill with a Table Leg. |
| You've Wasted Your Life (Bronze) | Idle for five minutes. |
