| A Man for All Seasons (Bronze) | Unlock 10 Classic Player Cards |
| Absolute Power (Bronze) | Hit 40 Home run in a season with one player (play at least 20 games) |
| All the Tea... (Bronze) | Unlock all 320 Cards |
| Alone at the Top (Bronze) | Win the world series in Postseason Mode (Play Final Game) |
| Bicentennial Man (Bronze) | Strike out 200 batters in a season with one player (play at least 20 games) |
| Cat Burglar (Bronze) | Steal 6 bases in one game |
| Catch Me If You Can (Bronze) | Steal 25 bases with your User Profile |
| Centennial Man (Bronze) | Drive in 100 runs in a season with one player (play at least 20 games) |
| Chicks Dig the Long Ball (Bronze) | Win the Classic Home Run Derby? |
| Crushers (Bronze) | Unlock all the batter cards in the game |
| Even More Long Balls (Bronze) | Hit 50 Home Runs with your User Profile |
| Expect the Unexpected (Bronze) | Drive in a run with a pitcher during a game |
| Feel the Heat (Bronze) | Strike out 25 batters with your User Profile |
| Flawless (Bronze) | Win a game without allowing any runs scored |
| Good Things Always Happen in 3's (Bronze) | Hit three Home Runs in a game |
| Grab Some Pine (Bronze) | Strike out 12 batters in one game |
| Grand Poobah (Platinum) | Unlock all Trophies |
| Hard Knocks (Bronze) | Hit three batters in a row |
| Has Anyone Seen the Fat Lady? (Bronze) | Score 15 Runs in a game |
| Hurlers (Bronze) | Unlock all the pitcher cards in the game |
| I Could Have Been a Contender (Bronze) | Play a Ranked Game Online |
| If You Build It… (Bronze) | Create a Card Team |
| It's a Good Day to be a Hitter (Bronze) | Hit four Home Runs in a game |
| It's Alive! (Bronze) | Create a Player |
| King of the Hill (Bronze) | Get to the top of the Best of the Best ladder in Home Run Derby? Mode |
| Long Balls (Bronze) | Hit 25 Home Runs with your User Profile |
| Man-Crush (Bronze) | Hit a home run with Tim Lincecum |
| May the Best Man... (Bronze) | Win 20 Games in a season with one pitcher (play at least 20 games) |
| One Hundo (Bronze) | Unlock 100 cards |
| Pining Away (Bronze) | Strike out 15 batters in one game |
| Show Stopper (Bronze) | Save 40 games in a season with one player (play at least 20 games) |
| Slippery When Wet (Bronze) | Steal 50 bases with your User Profile |
| Spread the Wealth (Bronze) | Unlock one card on each of the 30 MLB teams |
| Spring Training (Bronze) | Try all 4 Practice Modes |
| Sticky Fingers (Bronze) | Steal 4 bases in one game |
| Team 2K (Gold) | Beat a Team 2K member or someone that has unlocked this achievement in an online game |
| Teamwork (Bronze) | Unlock all nine cards for one team |
| That Guy's Not Throwing it Nice (Bronze) | Strike out 50 batters with your User Profile |
| That's All Folks (Silver) | Hit a home run to win a game |
| The Most Long Balls (Bronze) | Hit 100 Home Runs with your User Profile |
| There Can be Only One (Bronze) | Win the World Series in Franchise mode (play at least 20 games) |
| There's a Hole in My Bat (Bronze) | Strike out 100 batters with your User Profile |
| This Old Man Came Rolling Home (Silver) | Steal Home |
| Two Hundo (Bronze) | Unlock 200 cards |
| Two Turn Tables... (Bronze) | Create a 2K beats Playlist |
| Unhittable (Silver) | Don't give up any hits in a game |
| Unstoppable (Bronze) | Score 10 Runs in a game |
| Untouchable (Gold) | Throw a No Hitter with one pitcher in a game |
| Vicious Cycle (Silver) | Hit a home run, triple, double and single in one game with one player |
| Ya Can't Get Fooled Again (Silver) | Strike out a batter and throw out a runner on the same play |
