| Air Support Master (Bronze) | Destroy 100 BHolders in The Missing Link's and B.O.B.'s levels in Coop. |
| Around the World (Bronze) | Use the Pole Vault for the first time. |
| Art Aficionado (Bronze) | Buy every concept art. |
| Be My Guest (Gold) | Get a score of 10,000,000. |
| Bring it On (Bronze) | Defeat a Beam Bot without getting hurt. |
| Bull Rider (Bronze) | Destroy 10 Turrets using the Rodeo mode while climbing with The Missing Link. |
| Can't Get Enough! (Bronze) | Defeat 100 enemies with The Missing Link. |
| Casual Collector (Bronze) | Collect 100,000 Monsters DNA particles in the game. |
| Collateral Damage (Bronze) | Destroy 30 EyeScouts and Helicopters in Ginormica's levels in Coop. |
| Could I be any better than this? (Silver) | Defeat 300 enemies with The Missing Link. |
| Could we Fight Something Bigger? (Bronze) | Complete Chapter 3. |
| Cowboy Master (Bronze) | Destroy 30 Turrets using the Rodeo mode while climbing with The Missing Link. |
| Defying Gravity (Bronze) | Jump 150 times with each monster. |
| Expert Pitcher (Bronze) | Throw 25 enemies with The Missing Link. |
| Flying Fish (Bronze) | Perform 50 Leap Attacks with The Missing Link. |
| Full Arsenal (Bronze) | Buy all upgrades for all characters (Green nodes). |
| Get Out of the Way (Bronze) | Use Ginormica's Chain Dash for the first time. |
| Glutton (Bronze) | Swallow 20 enemies/objects with B.O.B. |
| Gold Olympic Champion (Gold) | Get a Gold Medal for all Monster Challenges. |
| Gourmet (Silver) | Swallow 50 enemies/objects with B.O.B. |
| Great Tackler (Bronze) | Destroy 10 drones with Ginormica's dash. |
| Is There a Way Out? (Bronze) | Complete Chapter 1. |
| Just Warming Up (Bronze) | Defeat 50 enemies with The Missing Link. |
| Machine gun specialist (Bronze) | Complete one B.O.B. Turret sequence without being hurt. |
| Master Tackler (Bronze) | Destroy 25 drones with Ginormica's dash. |
| Maximum Attraction (Bronze) | Tractor Beam 50 enemies in The The Missing Link's and B.O.B. levels in Coop. |
| Monsters vs Aliens Champion (Platinum) | Unlock all 45 trophies to earn this. |
| My Thumb Hurts (Bronze) | Get a score of 5,000,000. |
| Never Say Enough (Gold) | Collect 500,000 Monsters DNA particles in the game. |
| Not a Novice Anymore (Silver) | Complete the game (awarded just before credits). |
| Olympic Champion (Bronze) | Get any Medal for all Monster Challenges. |
| Pinball Fan (Bronze) | Use the Bumpers for the first time. |
| Remember the Heroes (Gold) | Complete the game without failing more than 10 times. |
| Safety First (Bronze) | Activate B.O.B.'s Shield for the first time. |
| San Francisco is safe, next! (Bronze) | Complete Chapter 2. |
| Shopping Frenzy (Bronze) | Buy all surprises (Purple nodes). |
| Stay Put and Watch (Bronze) | Watch credits until the end. |
| Strike with Attitude (Bronze) | Use The Missing Link's Leap Attack for the first time. |
| Strong Attraction (Bronze) | Use the Tractor Beam for the first time in Coop. |
| Team Glory (Silver) | Complete Chapter 3 without failing more than 10 times. |
| Team Spirit (Bronze) | Complete Chapter 1 without failing more than 10 times. |
| Team Supremacy (Silver) | Complete Chapter 4 without failing more than 10 times. |
| Team Victory (Bronze) | Complete Chapter 2 without failing more than 10 times. |
| That's a Blast (Bronze) | Use the Charge Blast for the first time in Coop. |
| Two is Better than One (Bronze) | Buy all coop upgrades. |
| What Alien Menace? (Bronze) | Complete Chapter 4. |
