| 100 Whacked (Bronze) | Kill 100 mobsters. |
| 25 Massacred (Bronze) | Kill 25 mobsters. |
| 250 Iced (Bronze) | Kill 250 mobsters. |
| 500 Empty suites (Bronze) | Kill 500 Mobsters. |
| 750 Sleeping With The Fishes (Silver) | Kill 750 mobsters. |
| Accept This As A Gift (Silver) | Earn one of each favor. |
| Ambush (Bronze) | Eliminate four rival families. |
| Bag Man (Silver) | Heist each bank once. |
| Bank Job (Bronze) | Heist your first bank. |
| BlackHand Brutality (Bronze) | Kill 25 mobsters only using BlackHand attacks. |
| CIA? DOA (Bronze) | Kill Henry Mitchell. |
| Contract Killer (Bronze) | Eliminate 5 made men with the appropriate kill condition. |
| Double Crossed (Bronze) | Eliminate two rival families. |
| Enforcer (Bronze) | Complete 10 execution styles. |
| Executions In Style (gold) | Complete all execution styles. |
| First Crime Ring (Silver) | Control one crime ring. |
| Five Crime Rings (Bronze) | Control five crime rings. |
| Fortified Venue (Bronze) | Max out all guards at a venue. |
| Full Of Lead (Bronze) | Kill 150 mobsters only using firearms. |
| Getting Made (Bronze) | Recruit your first soldier. |
| Gun Smuggler (Bronze) | Find a level 2 firearm upgrade. |
| It's Not Personal (Silver) | Eliminate a rival family by successfully bombing their compound. |
| It's Only Business (Gold) | Eliminate Hyman Roth. |
| Last Family Standing (Silver) | Eliminate all five rival families. |
| Let Me Upgrade You (Bronze) | Upgrade one of your made men’s skills or weapons. |
| Lockpicker (Bronze) | Crack five safes. |
| MobFace (Bronze) | Create a mobster using MobFace. |
| Modified Firepower (Bronze) | Find a level 3 firearm upgrade. |
| Organized Crime (Gold) | Control all crime rings. |
| Paying Tribute (Bronze) | Unlock all safehouses. |
| Platinum Trophy | Act like a mobster, think like a Don. |
| Pulling The Strings (Bronze) | Send your men to attack a venue from the Don’s View. |
| Right Hand Man (Bronze) | Promote one of your made men to Capo. |
| Safecracker (Gold) | Crack all safes. |
| Second In Command (Bronze) | Promote one of your men to Underboss. |
| Shakedown (Silver) | Control all extortable businesses. |
| The Counselor (Bronze) | Accept Tom Hagen as your Consigliere. |
| This Thing Of Ours (Silver) | Recruit a full family tree. |
| Three Crime Rings (Bronze) | Control three crime rings. |
| Torch The Joint (Bronze) | Send your men to bomb a venue from the Don’s View. |
| Vendetta (Bronze) | Eliminate three rival families. |
| Welcome To The Gun Show (Silver) | Collect all level 2 and level 3 firearm upgrades. |
