| 100 Whacked (15) | Kill 100 mobsters. |
| 25 Massacred (10) | Kill 25 mobsters. |
| 250 Iced (20) | Kill 250 mobsters. |
| 500 Empty Suits (25) | Kill 500 mobsters. |
| 750 Sleeping With The Fishes (30) | Kill 750 mobsters. |
| Accept This As A Gift (30) | Earn one of each favor. |
| Ambush (40) | Eliminate four rival families. |
| Bag Man (20) | Heist each bank once. |
| Bank Job (5) | Heist your first bank. |
| BlackHand Brutality (10) | Kill 25 mobsters only using BlackHand attacks. |
| CIA? DOA (25) | Kill Henry Mitchell. |
| Contract Killer (15) | Eliminate 5 made men with the appropriate kill condition. |
| Double Crossed (20) | Eliminate two rival families. |
| Enforcer (15) | Complete 10 execution styles. |
| Executions In Style (75) | Complete all execution styles. |
| First Crime Ring (15) | Control one crime ring. |
| Five Crime Rings (50) | Control five crime rings. |
| Fortified Venue (5) | Max out all guards at a venue. |
| Full Of Lead (10) | Kill 150 mobsters only using firearms. |
| Getting Made (5) | Recruit your first soldier. |
| Gun Smuggler (10) | Find a level 2 firearm upgrade. |
| It's Not Personal (20) | Eliminate a rival family by successfully bombing their compound. |
| It's Only Business (75) | Eliminate Hyman Roth. |
| Last Family Standing (50) | Eliminate all five rival families. |
| Let Me Upgrade You (5) | Upgrade one of your made men's skills or weapons. |
| Lockpicker (5) | Crack five safes. |
| MobFace (5) | Create a mobster using MobFace. |
| Modified Firepower (20) | Find a level 3 firearm upgrade. |
| Organized Crime (75) | Control all crime rings. |
| Paying Tribute (10) | Unlock all safehouses. |
| Pulling The Strings (5) | Send your men to attack a venue from the Don's View. |
| Right Hand Man (10) | Promote one of your made men to Capo. |
| Safecracker (75) | Crack all safes. |
| Second In Command (15) | Promote one of your made men to Underboss. |
| Shakedown (25) | Control all extortable businesses. |
| The Counselor (25) | Accept Tom Hagen as your Consigliere. |
| This Thing Of Ours (25) | Recruit a full family tree. |
| Three Crime Rings (40) | Control three crime rings. |
| Torch The Joint (5) | Send your men to bomb a venue from the Don's View. |
| Vendetta (30) | Eliminate three rival families. |
| Welcome To The Gun Show (30) | Collect all level 2 and 3 firearm upgrades. |
